Microanatomy of the Liver (The Hepatic Lobule)
Functional Unit: The Hepatic Lobule is the structural and functional unit of the liver, hexagon-shaped with a central vein.
Hepatocytes: Liver cells that process nutrients, produce bile, and detoxify toxins.
Kupffer Cells: Specialized macrophages located in the liver sinusoids that destroy aged red blood cells and bacteria.
Portal Triad: Located at the corners of the lobule, containing a branch of the hepatic artery, hepatic portal vein, and bile duct.
Clinical Significance: Damage to these lobules (as seen in Cirrhosis) leads to portal hypertension and impaired detoxification, frequently managed in critical care.
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