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![🇮🇳దేశం - MEGALOBLASTIC ANEMIA Impaired DNA synthesis (due to vitamin] B12 or folate deficiency medications) delaged maturation ofnucleus of precursor cells cgtoplasm in bone marrow relative to maturation Of VIt B12 DEFICIENCY FOLATEDEFICIENGY CAUSES pancreatic insufficiency leg pernicious anemia malnutrition chronic alcohol over use (eg drugs (e9 trimethoprim malabsorption Cronn disedse), metnotrexate insufficient intake (veganism) malabsorption gastrectomy phenytoin) Diphgllobothrium Iotum (fish tqpeworm B9 (e९ hemolytic anemia requirement leg drugs proton pump inhibitors 812 pregnancப FOLICACID [PPIs] antacids; metformin). 0 HISTORYIPE Does not cause neurologic sumptoms: neurologic_symptoms reversible dementia & subacute combined degeneration of thel @Folate supplementation in vitomin 812 spinal cord involving: deficiency can correct the anemia; the spinocerebellar tract lateral but it worsens neurologic symptoms corticospinal tract (causing motor & upper Vitamin B12 is required in fatty acid motor neuron [UMN] signs pathwaus and muelin_sunthesis dorsal column (causing sensory &lower [LMN] signs) motor neuron LABS methglmalonic acid (MMA) and homocgsteine Normal MMA and homocusteine Megaloblastic anemia presents with fatigue pallor glossitis loss' cheilosis diarrhea of appetite and headache DRUG-RELATED CAUSES Drugs that interfere with DNA synthesis HYPERSEGMENTATION include chemotherapeutic agents The nucleus of this (methotrexate 6-mercaptopurine) hgpersegmented neutrophil SUBACUTE COMBINED DEGENERATION nas six obes | six or more Seen in vitamin B12 deficiency & presents as required) nuclear lobes are peripheral neuropathg vibration, proprioception This is characteristic dysfunction, dementia, and spasticity finding of megaloblastic A MEGALOBLASTIC ANEMIA Impaired DNA synthesis (due to vitamin] B12 or folate deficiency medications) delaged maturation ofnucleus of precursor cells cgtoplasm in bone marrow relative to maturation Of VIt B12 DEFICIENCY FOLATEDEFICIENGY CAUSES pancreatic insufficiency leg pernicious anemia malnutrition chronic alcohol over use (eg drugs (e9 trimethoprim malabsorption Cronn disedse), metnotrexate insufficient intake (veganism) malabsorption gastrectomy phenytoin) Diphgllobothrium Iotum (fish tqpeworm B9 (e९ hemolytic anemia requirement leg drugs proton pump inhibitors 812 pregnancப FOLICACID [PPIs] antacids; metformin). 0 HISTORYIPE Does not cause neurologic sumptoms: neurologic_symptoms reversible dementia & subacute combined degeneration of thel @Folate supplementation in vitomin 812 spinal cord involving: deficiency can correct the anemia; the spinocerebellar tract lateral but it worsens neurologic symptoms corticospinal tract (causing motor & upper Vitamin B12 is required in fatty acid motor neuron [UMN] signs pathwaus and muelin_sunthesis dorsal column (causing sensory &lower [LMN] signs) motor neuron LABS methglmalonic acid (MMA) and homocgsteine Normal MMA and homocusteine Megaloblastic anemia presents with fatigue pallor glossitis loss' cheilosis diarrhea of appetite and headache DRUG-RELATED CAUSES Drugs that interfere with DNA synthesis HYPERSEGMENTATION include chemotherapeutic agents The nucleus of this (methotrexate 6-mercaptopurine) hgpersegmented neutrophil SUBACUTE COMBINED DEGENERATION nas six obes | six or more Seen in vitamin B12 deficiency & presents as required) nuclear lobes are peripheral neuropathg vibration, proprioception This is characteristic dysfunction, dementia, and spasticity finding of megaloblastic A - ShareChat](https://cdn4.sharechat.com/bd5223f_s1w/compressed_gm_40_img_46758_288d14a4_1763532045365_sc.jpg?tenant=sc&referrer=user-profile-service%2FrequestType50&f=365_sc.jpg "🇮🇳దేశం - MEGALOBLASTIC ANEMIA Impaired DNA synthesis (due to vitamin] B12 or folate deficiency medications) delaged maturation ofnucleus of precursor cells cgtoplasm in bone marrow relative to maturation Of VIt B12 DEFICIENCY FOLATEDEFICIENGY CAUSES pancreatic insufficiency leg pernicious anemia malnutrition chronic alcohol over use (eg drugs (e9 trimethoprim malabsorption Cronn disedse), metnotrexate insufficient intake (veganism) malabsorption gastrectomy phenytoin) Diphgllobothrium Iotum (fish tqpeworm B9 (e९ hemolytic anemia requirement leg drugs proton pump inhibitors 812 pregnancப FOLICACID [PPIs] antacids; metformin). 0 HISTORYIPE Does not cause neurologic sumptoms: neurologic_symptoms reversible dementia & subacute combined degeneration of thel @Folate supplementation in vitomin 812 spinal cord involving: deficiency can correct the anemia; the spinocerebellar tract lateral but it worsens neurologic symptoms corticospinal tract (causing motor & upper Vitamin B12 is required in fatty acid motor neuron [UMN] signs pathwaus and muelin_sunthesis dorsal column (causing sensory &lower [LMN] signs) motor neuron LABS methglmalonic acid (MMA) and homocgsteine Normal MMA and homocusteine Megaloblastic anemia presents with fatigue pallor glossitis loss' cheilosis diarrhea of appetite and headache DRUG-RELATED CAUSES Drugs that interfere with DNA synthesis HYPERSEGMENTATION include chemotherapeutic agents The nucleus of this (methotrexate 6-mercaptopurine) hgpersegmented neutrophil SUBACUTE COMBINED DEGENERATION nas six obes | six or more Seen in vitamin B12 deficiency & presents as required) nuclear lobes are peripheral neuropathg vibration, proprioception This is characteristic dysfunction, dementia, and spasticity finding of megaloblastic A MEGALOBLASTIC ANEMIA Impaired DNA synthesis (due to vitamin] B12 or folate deficiency medications) delaged maturation ofnucleus of precursor cells cgtoplasm in bone marrow relative to maturation Of VIt B12 DEFICIENCY FOLATEDEFICIENGY CAUSES pancreatic insufficiency leg pernicious anemia malnutrition chronic alcohol over use (eg drugs (e9 trimethoprim malabsorption Cronn disedse), metnotrexate insufficient intake (veganism) malabsorption gastrectomy phenytoin) Diphgllobothrium Iotum (fish tqpeworm B9 (e९ hemolytic anemia requirement leg drugs proton pump inhibitors 812 pregnancப FOLICACID [PPIs] antacids; metformin). 0 HISTORYIPE Does not cause neurologic sumptoms: neurologic_symptoms reversible dementia & subacute combined degeneration of thel @Folate supplementation in vitomin 812 spinal cord involving: deficiency can correct the anemia; the spinocerebellar tract lateral but it worsens neurologic symptoms corticospinal tract (causing motor & upper Vitamin B12 is required in fatty acid motor neuron [UMN] signs pathwaus and muelin_sunthesis dorsal column (causing sensory &lower [LMN] signs) motor neuron LABS methglmalonic acid (MMA) and homocgsteine Normal MMA and homocusteine Megaloblastic anemia presents with fatigue pallor glossitis loss' cheilosis diarrhea of appetite and headache DRUG-RELATED CAUSES Drugs that interfere with DNA synthesis HYPERSEGMENTATION include chemotherapeutic agents The nucleus of this (methotrexate 6-mercaptopurine) hgpersegmented neutrophil SUBACUTE COMBINED DEGENERATION nas six obes | six or more Seen in vitamin B12 deficiency & presents as required) nuclear lobes are peripheral neuropathg vibration, proprioception This is characteristic dysfunction, dementia, and spasticity finding of megaloblastic A - ShareChat")
![🇮🇳దేశం - DOGICAT BITES Tetanus Prophyllaxis Assess Wound Severity Give TTinjection Category |: Touching/licks if not up to date on intact skin No PEP needed Category Il: Minor scratches without bleeding] Vaccine only. +ED Category Ill: Transdermal bitelscratch or saliva on mucosa > Vaccine Rabies Immunoglobulin (RIG) Antibiotic Prophylaxis Post-Exposure Prophylaxis (PEP) For deepor Vaccine contaminated Intramuscular regimen wounds (Essen schedule): Days ೦, Amoxicillin- 3, 7,14, 28. clavulanate is Intradermal regimen: Days] preferred 0, 3, 7, 28 (two sites per visit) . RIG (for Category Ill only): Human RIG (HRIG): 20 IU/kg body weight: Equine RIG (ERIG): 40 IU/kg Infiltrate as much as possible around thel wound; remainder IM at ೩ site distant from vaccine DOGICAT BITES Tetanus Prophyllaxis Assess Wound Severity Give TTinjection Category |: Touching/licks if not up to date on intact skin No PEP needed Category Il: Minor scratches without bleeding] Vaccine only. +ED Category Ill: Transdermal bitelscratch or saliva on mucosa > Vaccine Rabies Immunoglobulin (RIG) Antibiotic Prophylaxis Post-Exposure Prophylaxis (PEP) For deepor Vaccine contaminated Intramuscular regimen wounds (Essen schedule): Days ೦, Amoxicillin- 3, 7,14, 28. clavulanate is Intradermal regimen: Days] preferred 0, 3, 7, 28 (two sites per visit) . RIG (for Category Ill only): Human RIG (HRIG): 20 IU/kg body weight: Equine RIG (ERIG): 40 IU/kg Infiltrate as much as possible around thel wound; remainder IM at ೩ site distant from vaccine - ShareChat](https://cdn4.sharechat.com/bd5223f_s1w/compressed_gm_40_img_29770_3addc6b1_1763532028255_sc.jpg?tenant=sc&referrer=user-profile-service%2FrequestType50&f=255_sc.jpg "🇮🇳దేశం - DOGICAT BITES Tetanus Prophyllaxis Assess Wound Severity Give TTinjection Category |: Touching/licks if not up to date on intact skin No PEP needed Category Il: Minor scratches without bleeding] Vaccine only. +ED Category Ill: Transdermal bitelscratch or saliva on mucosa > Vaccine Rabies Immunoglobulin (RIG) Antibiotic Prophylaxis Post-Exposure Prophylaxis (PEP) For deepor Vaccine contaminated Intramuscular regimen wounds (Essen schedule): Days ೦, Amoxicillin- 3, 7,14, 28. clavulanate is Intradermal regimen: Days] preferred 0, 3, 7, 28 (two sites per visit) . RIG (for Category Ill only): Human RIG (HRIG): 20 IU/kg body weight: Equine RIG (ERIG): 40 IU/kg Infiltrate as much as possible around thel wound; remainder IM at ೩ site distant from vaccine DOGICAT BITES Tetanus Prophyllaxis Assess Wound Severity Give TTinjection Category |: Touching/licks if not up to date on intact skin No PEP needed Category Il: Minor scratches without bleeding] Vaccine only. +ED Category Ill: Transdermal bitelscratch or saliva on mucosa > Vaccine Rabies Immunoglobulin (RIG) Antibiotic Prophylaxis Post-Exposure Prophylaxis (PEP) For deepor Vaccine contaminated Intramuscular regimen wounds (Essen schedule): Days ೦, Amoxicillin- 3, 7,14, 28. clavulanate is Intradermal regimen: Days] preferred 0, 3, 7, 28 (two sites per visit) . RIG (for Category Ill only): Human RIG (HRIG): 20 IU/kg body weight: Equine RIG (ERIG): 40 IU/kg Infiltrate as much as possible around thel wound; remainder IM at ೩ site distant from vaccine - ShareChat")